Controlled release of enrofloxacin by vanillin-crosslinked chitosan-polyvinyl alcohol blends
Materials Science and Engineering: C, ISSN: 0928-4931, Vol: 126, Page: 112125
2021
- 38Citations
- 48Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations38
- Citation Indexes38
- 38
- CrossRef12
- Captures48
- Readers48
- 48
Article Description
In transdermal drug delivery applications uniform drug distribution and sustained release are of great importance to decrease the side effects. In this direction in the present research, vanillin crosslinked chitosan (CS) and polyvinyl alcohol (PVA) blend based matrix-type transdermal system was prepared by casting and drying of aqueous solutions for local delivery of enrofloxacin (ENR) drug. Subsequently, the properties including the morphology, chemical structure, thermal behavior, tensile strength, crosslinking degree, weight uniformity, thickness, swelling and drug release of the CS-PVA blend films before and after crosslinking were characterized. In vitro drug release profiles showed the sustained release of ENR by the incorporation of vanillin as a crosslinker into the CS-PVA polymer matrix. Furthermore, the release kinetic profiles revealed that the followed mechanism for all samples was Higuchi and the increase of vanillin concentration in the blend films resulted in the change of diffusion mechanism from anomalous transport to Fickian diffusion. Overall, the obtained results suggest that the investigated vanillin crosslinked CS-PVA matrix-type films are potential candidates for transdermal drug delivery system.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0928493121002642; http://dx.doi.org/10.1016/j.msec.2021.112125; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85104802406&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34082942; https://linkinghub.elsevier.com/retrieve/pii/S0928493121002642; https://dx.doi.org/10.1016/j.msec.2021.112125
Elsevier BV
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