Phenylboronic acid conjugated to doxorubicin nanocomplexes as an anti-cancer drug delivery system in hepatocellular carcinoma
Nanomedicine: Nanotechnology, Biology and Medicine, ISSN: 1549-9634, Vol: 34, Page: 102389
2021
- 9Citations
- 26Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations9
- Citation Indexes9
- Captures26
- Readers26
- 26
Article Description
Anti-cancer strategies using nanocarrier systems have been explored in a variety of cancers; these systems can easily be incorporated into tumors via the enhanced permeability and retention (EPR) effect leading to enhanced anti-tumor activity while reducing systemic toxicity by specific tumor-targeting. The prognosis of hepatocellular carcinoma (HCC) is extremely poor when the condition is diagnosed at the unresectable stage as treatment options are limited. In order to improve the treatment of cancer and the overall anti-cancer effect, polymerized phenylboronic acid conjugated doxorubicin (pPBA-Dox) nanocomplexes were generated, and conjugated doxorubicin, which is conventionally used in HCC. The nanocomplexes exhibited enhanced anti-tumor activity via tumor-specific targeting in the subcutaneous and orthotopic HCC syngeneic mice tumor model, implying that the nanocomplexes facilitate the targeted Dox delivery to liver cancer in which the sialic acid is over-expressed. Therefore, this study provides insight into the novel targeted therapy using the nanocomplexes for the treatment of HCC.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1549963421000320; http://dx.doi.org/10.1016/j.nano.2021.102389; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85106550723&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/33753281; https://linkinghub.elsevier.com/retrieve/pii/S1549963421000320; https://dx.doi.org/10.1016/j.nano.2021.102389
Elsevier BV
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