Comparison of passive targeted delivery of inorganic and organic nanocarriers among different types of tumors
Nanomedicine: Nanotechnology, Biology and Medicine, ISSN: 1549-9634, Vol: 59, Page: 102753
2024
- 5Citations
- 17Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations5
- Citation Indexes5
- Captures17
- Readers17
- 17
Article Description
In this study, we have considered four types of nanoparticles (NPs): polylactic acid (PLA), gold (Au), calcium carbonate (CaCO 3 ), and silica (SiO 2 ) with similar sizes (TEM: 50–110 nm and DLS: 110–140 nm) to examine their passive accumulation in three different tumors: colon (CT26), melanoma (B16-F10), and breast (4T1) cancers. Our results demonstrate that each tumor model showed a different accumulation of NPs, in the following order: CT26 > B16-F10 > 4T1. The Au and PLA NPs were evidently characterized by a higher delivery efficiency in case of CT26 tumors compared to CaCO 3 and SiO 2 NPs. The Au NPs demonstrated the highest accumulation in B16-F10 cells compared to other NPs. These results were verified using SPECT, ex vivo fluorescence bioimaging, direct radiometry and histological analysis. Thus, this work contributes to new knowledge in passive tumor targeting of NPs and can be used for the development of new strategies for delivery of bioactive compounds.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1549963424000224; http://dx.doi.org/10.1016/j.nano.2024.102753; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85193441491&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38734039; https://linkinghub.elsevier.com/retrieve/pii/S1549963424000224; https://dx.doi.org/10.1016/j.nano.2024.102753
Elsevier BV
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