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PTSD co-morbid with HIV: Separate but equal, or two parts of a whole?

Neurobiology of Disease, ISSN: 0969-9961, Vol: 92, Issue: Pt B, Page: 116-123
2016
  • 64
    Citations
  • 0
    Usage
  • 121
    Captures
  • 2
    Mentions
  • 238
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    64
  • Captures
    121
  • Mentions
    2
    • News Mentions
      2
      • News
        2
  • Social Media
    238
    • Shares, Likes & Comments
      238
      • Facebook
        238

Most Recent News

An Analysis of Post-Traumatic Stress Disorder and Quality of Life Among Adults Living with HIV in Western Uganda

Background HIV/AIDS is still a major global public health concern that has a profound effect on people who are infected.1 The World Health Organization (WHO)

Review Description

Approximately 30 million people currently live with HIV worldwide and the incidence of stress-related disorders, such as post-traumatic stress disorder (PTSD), is elevated among people living with HIV as compared to those living without the virus. PTSD is a severely debilitating, stress-related psychiatric illness associated with trauma exposure. Patients with PTSD experience intrusive and fearful memories as well as flashbacks and nightmares of the traumatic event(s) for much of their lives, may avoid other people, and may be constantly on guard for new negative experiences. This review will delineate the information available to date regarding the comorbidity of PTSD and HIV and discuss the biological mechanisms which may contribute to the co-existence, and potential interaction of, these two disorders. Both HIV and PTSD are linked to altered neurobiology within areas of the brain involved in the startle response and altered function of the hypothalamic-pituitary-adrenal axis. Collectively, the data highlighted suggest that PTSD and HIV are more likely to actively interact than to simply co-exist within the same individual. Multi-faceted interactions between PTSD and HIV have the potential to alter response to treatment for either independent disorder. Therefore, it is of great importance to advance the understanding of the neurobiological substrates that are altered in comorbid PTSD and HIV such that the most efficacious treatments can be administered to improve both mental and physical health and reduce the spread of HIV.

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