Statistical optimization of process variables for the production of an anticancer drug (colchicine derivatives) through fermentation: at scale-up level
New Biotechnology, ISSN: 1871-6784, Vol: 28, Issue: 1, Page: 79-85
2011
- 16Citations
- 39Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations16
- Citation Indexes16
- CrossRef16
- 16
- Captures39
- Readers39
- 39
Article Description
Effect of various nutritional components and fermentation parameters on biotransformation of colchicine using Bacillus megaterium ACBT03 to produce 3-demethylated colchicine (3-DMC) has been investigated. Initially, Plackett–Burman (PB) design was used to evaluate the 11 nutritional variables to screen medium component that significantly influences the 3-demethylated colchicine (3-DMC) production. Three most statistically significant nutrients that is starch, glycerol and yeast extract were identified. Response surface methodology was used to optimize fermenter operational factors pH, temperature, impeller tip velocity and aeration rate for high 3-DMC production. The predicted results of 3-DMC yield (7689.13 mg/l) were obtained at 5-l-jar fermenter after optimization of pH 6.8, temperature 28°C, impeller tip velocity 4650 cm/min, and aeration rate 2.0 vvm. The validity of model was confirmed; and the optimum medium designed led a maximum 3-DMC yield of 7335 mg/l, which had 3–4% variation with predicted results. Furthermore, the experiment was scaled up in the 70-l fermenter.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1871678410005352; http://dx.doi.org/10.1016/j.nbt.2010.07.008; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=78650294479&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20647066; https://linkinghub.elsevier.com/retrieve/pii/S1871678410005352; https://dx.doi.org/10.1016/j.nbt.2010.07.008
Elsevier BV
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