The translocator protein (18 kDa) and its role in neuropsychiatric disorders
Neuroscience & Biobehavioral Reviews, ISSN: 0149-7634, Vol: 83, Page: 183-199
2017
- 26Citations
- 58Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations26
- Citation Indexes26
- 26
- CrossRef22
- Captures58
- Readers58
- 58
Review Description
Translocator protein (TSPO) is an 18 kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. TSPO is involved in cellular functions, including the regulation of cell proliferation, transport of cholesterol to the inner mitochondrial membranes of glial cells, regulation of mitochondrial quality control, and haem synthesis. In the brain, TSPO has been extensively used as a biomarker of injury and inflammation. Indeed, TSPO was up-regulated in several inflammatory and neurodegenerative diseases. In contrast, the expression of TSPO was decreased in peripheral blood from psychiatric patients. Since TSPO is involved in several mechanisms related to mitochondrial function and inflammatory alterations, therapeutic approaches focusing on the regulation of TSPO may provide a new avenue for the treatment of neuropsychiatric disorders. Based on the involvement of mitochondrial alterations in the neurobiology of neuropsychiatric disorders, this review will focus on the functions and physiological roles of TSPO and the potential of TSPO ligands as therapeutic strategies for the treatment of neuropsychiatric disorders.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0149763417304013; http://dx.doi.org/10.1016/j.neubiorev.2017.10.010; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85032879752&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/29054730; https://linkinghub.elsevier.com/retrieve/pii/S0149763417304013; https://dx.doi.org/10.1016/j.neubiorev.2017.10.010
Elsevier BV
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