Brain tissue volumes in relation to cognitive function and risk of dementia
Neurobiology of Aging, ISSN: 0197-4580, Vol: 31, Issue: 3, Page: 378-386
2010
- 114Citations
- 109Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations114
- Citation Indexes114
- 114
- CrossRef103
- Captures109
- Readers109
- 109
Article Description
We investigated in a population-based cohort study the association of global and lobar brain tissue volumes with specific cognitive domains and risk of dementia. Participants ( n = 490; 60–90 years) were non-demented at baseline (1995–1996). From baseline brain MRI-scans we obtained global and lobar volumes of CSF, GM, normal WM, white matter lesions and hippocampus. We performed neuropsychological testing at baseline to assess information processing speed, executive function, memory function and global cognitive function. Participants were followed for incident dementia until January 1, 2005. Larger volumes of CSF and WML were associated with worse performance on all neuropsychological tests, and an increased risk of dementia. Smaller WM volume was related to poorer information processing speed and executive function. In contrast, smaller GM volume was associated with worse memory function and increased risk of dementia. When investigating lobar GM volumes, we found that hippocampal volume and temporal GM volume were most strongly associated with risk of dementia, even in persons without objective and subjective cognitive deficits at baseline, followed by frontal and parietal GM volumes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0197458008001334; http://dx.doi.org/10.1016/j.neurobiolaging.2008.04.008; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=74149094288&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/18501994; https://linkinghub.elsevier.com/retrieve/pii/S0197458008001334; https://dx.doi.org/10.1016/j.neurobiolaging.2008.04.008
Elsevier BV
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