Multidimensional associations between cognition and connectome organization in temporal lobe epilepsy
NeuroImage, ISSN: 1053-8119, Vol: 213, Page: 116706
2020
- 54Citations
- 93Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations54
- Citation Indexes54
- 54
- CrossRef32
- Captures93
- Readers93
- 93
Article Description
Temporal lobe epilepsy (TLE) is known to affect large-scale structural networks and cognitive function in multiple domains. The study of complex relations between structural network organization and cognition requires comprehensive analytical methods and a shift towards multivariate techniques. Here, we sought to identify multidimensional associations between cognitive performance and structural network topology in TLE. We studied 34 drug-resistant adult TLE patients and 24 age- and sex-matched healthy controls. Participants underwent a comprehensive neurocognitive battery and multimodal MRI, allowing for large-scale connectomics, and morphological evaluation of subcortical and neocortical regions. Using canonical correlation analysis, we identified a multivariate mode that links cognitive performance to a brain structural network. Our approach was complemented by bootstrap-based hierarchical clustering to derive cognitive subtypes and associated patterns of macroscale connectome anomalies. Both methodologies provided converging evidence for a close coupling between cognitive impairments across multiple domains and large-scale structural network compromise. Cognitive classes presented with an increasing gradient of abnormalities (increasing cortical and subcortical atrophy and less efficient white matter connectome organization in patients with increasing degrees of cognitive impairments). Notably, network topology characterized cognitive performance better than morphometric measures did. Our multivariate approach emphasized a close coupling of cognitive dysfunction and large-scale network anomalies in TLE. Our findings contribute to understand the complexity of structural connectivity regulating the heterogeneous cognitive deficits found in epilepsy.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1053811920301932; http://dx.doi.org/10.1016/j.neuroimage.2020.116706; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85081701829&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32151761; https://linkinghub.elsevier.com/retrieve/pii/S1053811920301932; https://dx.doi.org/10.1016/j.neuroimage.2020.116706
Elsevier BV
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