Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia
Neuron, ISSN: 0896-6273, Vol: 99, Issue: 2, Page: 362-375.e4
2018
- 164Citations
- 221Captures
- 2Mentions
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations164
- Citation Indexes164
- 164
- CrossRef136
- Captures221
- Readers221
- 221
- Mentions2
- Blog Mentions1
- Blog1
- References1
- Wikipedia1
Most Recent Blog
Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel Disease
PreviousNext Cover ArticleResearch Articles, Neurobiology of Disease Targeting Astrocyte Signaling Alleviates Cerebrovascular and Synaptic Function Deficits in a Diet-Based Mouse Model of Small Cerebral Vessel
Article Description
Functional hyperemia, a regional increase of blood flow triggered by local neural activation, is used to map brain activity in health and disease. However, the spatial-temporal dynamics of functional hyperemia remain unclear. Two-photon imaging of the entire vascular arbor in NG2-creERT2;GCaMP6f mice shows that local synaptic activation, measured via oligodendrocyte precursor cell (OPC) Ca 2+ signaling, generates a synchronous Ca 2+ drop in pericytes and smooth muscle cells (SMCs) enwrapping all upstream vessels feeding the activated synapses. Surprisingly, the onset timing, direction, and amplitude of vessel diameter and blood velocity changes vary dramatically from juxta-synaptic capillaries back to the pial arteriole. These results establish a precise spatial-temporal sequence of vascular changes triggered by neural activity and essential for the interpretation of blood-flow-based imaging techniques such as BOLD-fMRI.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S089662731830480X; http://dx.doi.org/10.1016/j.neuron.2018.06.012; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85048553281&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/29937277; https://linkinghub.elsevier.com/retrieve/pii/S089662731830480X; https://dx.doi.org/10.1016/j.neuron.2018.06.012
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know