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The antidepressant-like effect of ethynyl estradiol is mediated by both serotonergic and noradrenergic systems in the forced swimming test

Neuroscience, ISSN: 0306-4522, Vol: 250, Page: 102-111
2013
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Article Description

17α-Ethynyl-estradiol (EE 2, a synthetic steroidal estrogen) induces antidepressant-like effects in the forced swimming test (FST) similar to those induced by 5-HT and noradrenaline reuptake inhibitors (dual antidepressants). However, the precise mechanism of action of EE 2 has not been studied.

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