Role of Triggers on the Structural and Functional Facets of TAR DNA-binding Protein 43
Neuroscience, ISSN: 0306-4522, Vol: 511, Page: 110-130
2023
- 1Citations
- 9Captures
- 2Mentions
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Most Recent News
Recent Findings from Trent University Provides New Insights into DNA-Binding Proteins (Role of Triggers On the Structural and Functional Facets of Tar Dna-binding Protein 43)
2023 MAY 15 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Daily -- Researchers detail new data in Proteins - DNA-Binding
Review Description
Nuclear TAR DNA-binding protein 43 (TDP-43) mitigates cellular function, but the dynamic nucleus-cytoplasm shuttling of TDP-43 is disrupted in diseases, such as Amyotrophic Lateral Sclerosis (ALS). The polymorphic nature of the TDP-43 structures in vitro and in vivo is a result of environmental factors leading to the protein pathogenesis. Once the triggers which mitigate TDP-43 biochemistry are identified, new therapies can be developed. This review aims to illustrate recent discoveries in the diversity of TDP-43 structures (amyloidogenic and non-amyloidogenic) and highlight the triggers which result in their formation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0306452222005838; http://dx.doi.org/10.1016/j.neuroscience.2022.11.027; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85146015983&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/36442745; https://linkinghub.elsevier.com/retrieve/pii/S0306452222005838; https://dx.doi.org/10.1016/j.neuroscience.2022.11.027
Elsevier BV
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