Effects of RFamide-related peptide-1 (RFRP-1) microinjections into the central nucleus of amygdala on passive avoidance learning in rats
Neuropeptides, ISSN: 0143-4179, Vol: 62, Page: 81-86
2017
- 5Citations
- 7Captures
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef4
- Captures7
- Readers7
Article Description
The amygdaloid body (AMY) plays an important role in memory, learning and reward-related processes. RFRP-1 immunoreactive fibers and NPFF receptors were identified in the AMY, and previously we verified that RFRP-1 infused into the central nucleus of AMY (CeA) induced place preference. The aim of the present study was to examine the possible effects of RFRP-1 in the CeA on passive avoidance learning. Male Wistar rats were examined in two-compartment passive avoidance paradigm. Animals were shocked with 0.5 mA current and subsequently were microinjected bilaterally with 50 ng or 100 ng RFRP-1 in volume of 0.4 μl, or 20 ng NPFF receptor antagonist RF9 (ANT) alone, or antagonist 15 min before 50 ng RFRP-1 treatments into the CeA. Fifty nanogram dose of RFRP-1 significantly increased the step-through latency time, the 100 ng RFRP-1 and the ANT alone were ineffective. The effect of 50 ng RFRP-1 was eliminated by the ANT pretreatment. Our results suggest that intraamygdaloid RFRP-1 enhances learning processes and memory in aversive situations and this effect can specifically be prevented by ANT pretreatment.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0143417916301111; http://dx.doi.org/10.1016/j.npep.2016.12.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85008195236&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/27993374; https://linkinghub.elsevier.com/retrieve/pii/S0143417916301111; https://dx.doi.org/10.1016/j.npep.2016.12.002
Elsevier BV
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