The phenotypic changes of Schwann cells promote the functional repair of nerve injury
Neuropeptides, ISSN: 0143-4179, Vol: 106, Page: 102438
2024
- 3Citations
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- 1Mentions
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Most Recent News
Researchers at Nanchang University Have Reported New Data on Nerve Injury (The Phenotypic Changes of Schwann Cells Promote the Functional Repair of Nerve Injury)
2024 AUG 01 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Daily News -- Current study results on Nervous
Review Description
Functional recovery after nerve injury is a significant challenge due to the complex nature of nerve injury repair and the non-regeneration of neurons. Schwann cells (SCs), play a crucial role in the nerve injury repair process because of their high plasticity, secretion, and migration abilities. Upon nerve injury, SCs undergo a phenotypic change and redifferentiate into a repair phenotype, which helps in healing by recruiting phagocytes, removing myelin fragments, promoting axon regeneration, and facilitating myelin formation. However, the repair phenotype can be unstable, limiting the effectiveness of the repair. Recent research has found that transplantation of SCs can be an effective treatment option, therefore, it is essential to comprehend the phenotypic changes of SCs and clarify the related mechanisms to develop the transplantation therapy further.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0143417924000374; http://dx.doi.org/10.1016/j.npep.2024.102438; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85192793231&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38749170; https://linkinghub.elsevier.com/retrieve/pii/S0143417924000374; https://dx.doi.org/10.1016/j.npep.2024.102438
Elsevier BV
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