Association between blood pressure and new onset of chronic kidney disease in non-diabetic Japanese adults: A population-based longitudinal study from 1998 to 2023
Nutrition, Metabolism and Cardiovascular Diseases, ISSN: 0939-4753, Vol: 34, Issue: 10, Page: 2395-2404
2024
- 3Citations
- 12Captures
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Article Description
Hypertension is a risk factor for developing chronic kidney disease (CKD). Studies of adult participants in the USA reported that hypertension increased the risk of developing CKD even in the non-diabetic population. However, studies in non-diabetic populations are limited and additional studies in other races are required. This study aimed to examine the relationship between hypertension and the development of CKD in non-diabetic Asian adults. In this longitudinal study, non-diabetic Japanese adults who took annual checkups from 1998 to 2023 were included. CKD was defined as <60 mL/min/1.73 m 2, and hypertension was classified into four levels according to the guidelines of the American College of Cardiology/American Heart Association. The Weibull accelerated failure time model was selected because the proportional hazards assumption was violated. Of the 7363 (men: 40.3%) people in the final cohort, 2498 (men: 40.1%) developed CKD after a mean follow-up of 7.99 years. Elevated blood pressure (BP) and hypertension stage 2 had a 9% (95% confidence interval [CI]: 1%–16%) and 11% (95% CI: 5%–17%) shorter survival time to CKD onset, respectively, than normal BP. Hypertension stage 1 also had a shorter survival to CKD onset by point estimate, but all 95% CIs crossed 1 in all models. In a relatively healthy Asian population without diabetes, controlling BP to an appropriate range reduces the risk of developing CKD.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S093947532400173X; http://dx.doi.org/10.1016/j.numecd.2024.05.005; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85195660540&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38866617; https://linkinghub.elsevier.com/retrieve/pii/S093947532400173X
Elsevier BV
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