Oral involvement of sinonasal undifferentiated carcinoma: A case report and immunohistochemical study of a challenging case
Oral Oncology, ISSN: 1368-8375, Vol: 126, Page: 105779
2022
- 2Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations2
- Citation Indexes2
- CrossRef2
- Captures9
- Readers9
Article Description
Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor highly aggressive most frequently arise in the maxillary sinus and nasal cavity. Oral involvement is extremely rare. A 62-years-old male presents a large infiltrative mass involving the hard palate and left alveolar ridge. Computed tomography showed bone destruction and invasion of paranasal sinuses and orbits. Histology revealed a malignant neoplasm consisting of small round cells with minimal cytoplasm and hyperchromatic nuclei without any connection with the oral mucosal epithelium. Immunohistochemical analysis showed epithelial origin (CK-7+, CK-20+, AE1/AE3+, EMA+) and lacked strong evidence of squamous and neuroendocrine differentiation (p63−, 34βE12−, NSE−/+, chromogranin−, synaptophysin−). TTF-1 negative ruled out the metastatic origin. A diagnosis of SNUC subtype positive for SMARCB1 (INI1) was reached. The patient was submitted to concurrent radiotherapy and chemotherapy without signs of recurrence after 2 years. SNUC involving the oral cavity is a rare malignancy that may mimic symptoms of dental infection or sinusitis. A careful correlation of clinical, microscopic, and immunohistochemical characteristics is mandatory for early diagnosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1368837522000689; http://dx.doi.org/10.1016/j.oraloncology.2022.105779; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85124771871&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35183913; https://linkinghub.elsevier.com/retrieve/pii/S1368837522000689; https://dx.doi.org/10.1016/j.oraloncology.2022.105779
Elsevier BV
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