Facial pain with localized and widespread manifestations: Separate pathways of vulnerability
PAIN®, ISSN: 0304-3959, Vol: 154, Issue: 11, Page: 2335-2343
2013
- 35Citations
- 58Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations35
- Citation Indexes35
- 35
- CrossRef25
- Captures58
- Readers58
- 58
- Mentions2
- News Mentions1
- News1
- References1
- Wikipedia1
Most Recent News
Genetic Variants Associated With Low Back Pain and Their Response to Treatment With Duloxetine or Propranolol
STUDY INFORMATION OFFICIAL TITLE: Genetic Variants Associated With the Occurrence of Localized Low Back Pain or Low Back Pain With Widespread Pain Symptoms, and Their
Article Description
Human association studies of common genetic polymorphisms have identified many loci that are associated with risk of complex diseases, although individual loci typically have small effects. However, by envisaging genetic associations in terms of cellular pathways, rather than any specific polymorphism, combined effects of many biologically relevant alleles can be detected. The effects are likely to be most apparent in investigations of phenotypically homogenous subtypes of complex diseases. We report findings from a case-control, genetic association study of relationships between 2925 single nucleotide polymorphisms (SNPs) and 2 subtypes of a commonly occurring chronic facial pain condition, temporomandibular disorder (TMD): 1) localized TMD and 2) TMD with widespread pain. When compared to healthy controls, cases with localized TMD differed in allelic frequency of SNPs that mapped to a serotonergic receptor pathway ( P = 0.0012), while cases of TMD with widespread pain differed in allelic frequency of SNPs that mapped to a T-cell receptor pathway ( P = 0.0014). A risk index representing combined effects of 6 SNPs from the serotonergic pathway was associated with greater odds of localized TMD (odds ratio 2.7, P = 1.3 E-09), and the result was reproduced in a replication case-control cohort study of 639 people (odds ratio 1.6, P = 0.014). A risk index representing combined effects of 8 SNPs from the T-cell receptor pathway was associated with greater odds of TMD with widespread pain ( P = 1.9 E-08), although the result was not significant in the replication cohort. These findings illustrate potential for clinical classification of chronic pain based on distinct molecular profiles and genetic background.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0304395913003771; http://dx.doi.org/10.1016/j.pain.2013.07.009; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84886236272&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/23867732; https://journals.lww.com/00006396-201311000-00015; https://dx.doi.org/10.1016/j.pain.2013.07.009; https://insights.ovid.com/article/00006396-201311000-00015
Ovid Technologies (Wolters Kluwer Health)
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