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Effects of working memory training in patients with Parkinson's disease without cognitive impairment: A randomized controlled trial

Parkinsonism & Related Disorders, ISSN: 1353-8020, Vol: 72, Page: 13-22
2020
  • 18
    Citations
  • 0
    Usage
  • 108
    Captures
  • 2
    Mentions
  • 12
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    18
  • Captures
    108
  • Mentions
    2
    • News Mentions
      1
      • News
        1
    • References
      1
      • Wikipedia
        1
  • Social Media
    12
    • Shares, Likes & Comments
      12
      • Facebook
        12

Most Recent News

Effects of working memory training in patients with Parkinson's disease without cognitive impairment: A randomized controlled trial.

Parkinsonism Relat Disord. 2020 Feb 11;72:13-22. Authors: Ophey A, Giehl K, Rehberg S, Eggers C, Reker P, van Eimeren T, Kalbe E PubMed: 32078917 Submit Comment

Article Description

To determine the feasibility and evaluate effects of a computerized working memory (WM) training (WMT) in patients with Parkinson's Disease (PD) on cognitive and clinical outcomes. 76 patients with PD without cognitive impairment were randomized to either the WMT group ( n  = 37), who participated in a 5-week adaptive WMT, or a passive waiting-list control group (CG, n  = 39). Patients underwent clinical and neuropsychological examination at baseline, after training, and at 3-months follow-up, with verbal WM and non-verbal WM as primary outcomes. Outcome assessors were blinded for group allocation. All WMT participants completed the training successfully and reported high levels of motivation for and satisfaction with the training. Repeated-measures, linear mixed-effects models revealed positive training effects for the WMT group compared to the CG in verbal working memory with a small relative effect size 0.39 [95%CI 0.05; 0.76] for the 3-months follow-up only. No other reliable training effects in cognitive and clinical variables were found for either point of time. In this randomized controlled trial, WMT was feasible and yielded some evidence for 3-months follow-up training gains in patients with PD. WMT might be an effective intervention to prevent cognitive decline in this patient group, however, more longitudinal studies with longer follow-up periods and more sensitive assessment tools will have to proof this concept. German Clinical Trials Register (DRKS00009379).

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