Effects of working memory training in patients with Parkinson's disease without cognitive impairment: A randomized controlled trial
Parkinsonism & Related Disorders, ISSN: 1353-8020, Vol: 72, Page: 13-22
2020
- 18Citations
- 108Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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- Citations18
- Citation Indexes16
- 16
- CrossRef8
- Policy Citations2
- Policy Citation2
- Captures108
- Readers108
- 108
- Mentions2
- News Mentions1
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Effects of working memory training in patients with Parkinson's disease without cognitive impairment: A randomized controlled trial.
Parkinsonism Relat Disord. 2020 Feb 11;72:13-22. Authors: Ophey A, Giehl K, Rehberg S, Eggers C, Reker P, van Eimeren T, Kalbe E PubMed: 32078917 Submit Comment
Article Description
To determine the feasibility and evaluate effects of a computerized working memory (WM) training (WMT) in patients with Parkinson's Disease (PD) on cognitive and clinical outcomes. 76 patients with PD without cognitive impairment were randomized to either the WMT group ( n = 37), who participated in a 5-week adaptive WMT, or a passive waiting-list control group (CG, n = 39). Patients underwent clinical and neuropsychological examination at baseline, after training, and at 3-months follow-up, with verbal WM and non-verbal WM as primary outcomes. Outcome assessors were blinded for group allocation. All WMT participants completed the training successfully and reported high levels of motivation for and satisfaction with the training. Repeated-measures, linear mixed-effects models revealed positive training effects for the WMT group compared to the CG in verbal working memory with a small relative effect size 0.39 [95%CI 0.05; 0.76] for the 3-months follow-up only. No other reliable training effects in cognitive and clinical variables were found for either point of time. In this randomized controlled trial, WMT was feasible and yielded some evidence for 3-months follow-up training gains in patients with PD. WMT might be an effective intervention to prevent cognitive decline in this patient group, however, more longitudinal studies with longer follow-up periods and more sensitive assessment tools will have to proof this concept. German Clinical Trials Register (DRKS00009379).
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1353802020300316; http://dx.doi.org/10.1016/j.parkreldis.2020.02.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079432431&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/32078917; https://linkinghub.elsevier.com/retrieve/pii/S1353802020300316; https://dx.doi.org/10.1016/j.parkreldis.2020.02.002
Elsevier BV
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