Modulation of skin microbiome in acne patients by aminolevulinic acid-photodynamic therapy
Photodiagnosis and Photodynamic Therapy, ISSN: 1572-1000, Vol: 36, Page: 102556
2021
- 11Citations
- 19Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations11
- Citation Indexes11
- 11
- CrossRef3
- Captures19
- Readers19
- 19
Article Description
Aminolevulinic acid-photodynamic therapy (ALA-PDT) has been an effective treatment for moderate to severe acne. However, the effect of ALA-PDT on skin microbiome in acne patients should also be examined.. To examine the composition, diversity, and resilience of skin microbiome in acne patients before and after ALA-PDT. A prospective study was conducted on five patients with moderate to severe acne. All patients underwent a 5% ALA-PDT at a two-week interval for four sessions. Epidermal and follicular samples of acne patients were acquired for 16S rRNA gene amplicon metasequencing at baseline and before the final session. ALA-PDT inhibited Cutibacterium acnes of follicular microbiome in acne. Follicular residential bacteria, mainly Bacillus and Lactococcus, rose in abundance after PDT. ALA-PDT increased the diversity of skin microbiome in acne and clustered follicular microbiome toward epidermal microbiome, both taxonomically and functionally. ALA-PDT exerts its therapeutic effect on acne partially through inhibiting C. acnes and modulating the composition and potential function of skin microbiome in acne.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S157210002100380X; http://dx.doi.org/10.1016/j.pdpdt.2021.102556; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116673995&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34600122; https://linkinghub.elsevier.com/retrieve/pii/S157210002100380X; https://dx.doi.org/10.1016/j.pdpdt.2021.102556
Elsevier BV
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