Uncaria rhynchophylla mediated Ag/NiO nanocomposites: A new insight for the evaluation of cytotoxicity, antibacterial and photocatalytic applications

The increase of microbial resistance poses threats to human health. Therefore, efficient treatment of microbial resistance is a global challenge.. During this study, the Ag/NiO nanocomposite was fabricated via simple and ecofriendly method, using Uncaria rhynchophylla extract as a reducing and capping agent to avoid the aggregation of as synthesized nanomaterials. Here, a range of characterization techniques were employed to characterize the sample which includes UV–vis spectroscopy, X-ray diffraction, FTIR spectroscopy, electron diffraction spectroscopy (EDX), scanning electron microscopy (SEM). Furthermore, the resultant nanocomposite demonstrated an efficient ability for the inhibition of both gram-positive and gram negative pathogenic multidrug resistant bacteria. Additionally, the Ag/NiO nanocomposite showed a durable antioxidant effect against DPPH that could still reach 63% at very low concentration, i.e. 0.5 mg/mL. Interestingly, the synthesized nanocomposite is efficient for the production of reactive oxygen species (ROS) and shows no hemolytic activity. Likewise, the Ag/NiO nanocomposite displayed excellent photocatalytic activity to degrade 85% methylene blue (MB) by 4 mg/25 mL and could be used for waste water treatment. It is believed that synthesized nanostructure with desirable morphology and preparation simplicity can be promising material for antimicrobial, antioxidant and catalytic applications.