Characteristics of the retina and choroid in fibromyalgia patients and their correlation with disease severity and quality of life

To evaluate retinal and choroidal characteristics of fibromyalgia (FM) patients using spectral-domain optical coherence tomography (SD-OCT), to compare them with healthy controls, and to determine the correlation of these measurements with disease severity and quality of life. Thirty-nine eyes of 39 patients with FM and 44 eyes of 44 age‐ and sex‐matched healthy subjects were enrolled. The retinal nerve fiber layer (RNFL), central macular thickness (CMT), and choroidal thickness (CT) measurements of the subjects were obtained using SD-OCT (Maestro, Topcon Co. Tokyo, Japan), choroidal vascular index (CVI) was calculated by using the binarization method and the results were compared. Disease duration (DD), widespread pain index (WPI), symptom severity scale (SSS), visual analog scale (VAS), ocular pain assessment survey (OPAS), FM impact questionnaire (FIQ), European Quality of Life-5 Dimensions-3 level (EQ-5D-3 L), European Quality VAS score (EQ-VAS) and use of pregabalin were recorded. Correlations between the SD-OCT results and the FM parameters were evaluated. No significant difference was found in terms of age and gender ( p  = 0.612, p  = 0.244 respectively). Patients in the FM group had significantly thinner RNFL superior quadrant and CT ( p  = 0,009 and p  < 0.001, respectively). CVI was significantly higher in the FM group ( p  < 0.001). There was an inverse correlation between OPAS and CT ( r  = -0.379, p  = 0.027) and between VAS and CVI ( r  = -0.398, p  = 0.020). The use of pregabalin had no effect on SD-OCT ( p  > 0.05). Patients with FM demonstrated reduced RNFL superior quadrant and CT and increased CVI. Ocular and general body pain in FM was found to be associated with SD-OCT.