Successful treatment by a chlorin e6 derivative mediated photodynamic therapy combined holmium laser for cervical and vaginal giant condyloma acuminata and low-grade intraepithelial neoplasia:A case report
Photodiagnosis and Photodynamic Therapy, ISSN: 1572-1000, Vol: 46, Page: 104022
2024
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Case Description
Photodynamic therapy (PDT) is proved effective for treating low-grade squamous intraepithelial lesions (LSIL) and condylomata acuminata (CA). 5-Aminolevulinicacid (5-ALA) is the most common applied photosensitizer, but high rate of unbearable pain and relative long incubation time were reported. Here, we report a 27-year-old woman suffering from cervical and vaginal giant CA with LSIL involving the whole right vaginal fornix, cervical surface, and vaginal wall. Holmium yttrium aluminum garnet (Ho: YAG) laser was first applied to remove the giant CA lesions. STBF, a derivative of chlorin e6 (Ce6) was then applied on suspicious lesions as a new photosensitizer for 1 h. Lesions were exposed to LED illumination with a wavelength of 630 nm and light dose of 200–284 J/cm 2 for cervical canal and the vaginal surfaces, 100–150 J/cm 2 for cervix surface. Vaginal giant CA and LSIL lesions got complete remission at 6-month follow-up. Mild tolerable adverse reactions were observed after STBF-PDT and relieved in 24 h. Thus, the combination of Ho: YAG laser and STBF-PDT may be a novel option for cervical and vaginal giant CA and LSIL, especially for special vaginal fornix areas.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1572100024000619; http://dx.doi.org/10.1016/j.pdpdt.2024.104022; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85186730329&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/38401820; https://linkinghub.elsevier.com/retrieve/pii/S1572100024000619; https://dx.doi.org/10.1016/j.pdpdt.2024.104022
Elsevier BV
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