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The asarone-derived phenylpropanoids from the rhizome of Acorus calamus var. angustatus Besser

Phytochemistry, ISSN: 0031-9422, Vol: 170, Page: 112212
2020
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Article Description

Phenylpropanoids comprise a broad spectrum of biologically active natural products. As part of our ongoing research on antiepileptic active compounds from traditional Chinese herb, Acorus calamus var. angustatus Besser, three undescribed phenylpropanoids and twenty-two known ones were isolated. All the undescribed structures were determined by a combination of 1D and 2D NMR, HRMS. In addition, γ -asaronol was identified as racemates and its absolute configuration were determined by the modified Mosher's method and ECD spectral data. Furthermore, some selected isolated compounds were evaluated for their cell viability and neuroprotective activities in H 2 O 2 -induced SH-SY5Y cells. α -Asaronol, β -asaronol, 3-(2,4,5-trimethoxyphenyl)propan-1-ol and 1,2,4-trimethoxy-5-(3-methoxypropyl)benzene exerted potential protective activity from neuronal oxidative stress in all test concentrations ranging from 0.01 to 100  μ M, in which the neuroprotective activity of β -asaronol was the best.

Bibliographic Details

Bai, Yajun; Sun, Ying; Xie, Jing; Li, Bin; Bai, Yujun; Zhang, Dongxu; Liang, Jing; Xiao, Chaoni; Zhong, Aiguo; Cao, Yanjun; Zheng, Xiaohui

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Agricultural and Biological Sciences

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