Short communication: Ex-vivo effects of fluoxetine on production of biomarkers for inflammation and neurodevelopment by the placenta
Placenta, ISSN: 0143-4004, Vol: 107, Page: 46-50
2021
- 2Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations2
- Citation Indexes2
- CrossRef1
- Captures10
- Readers10
- 10
Article Description
Fluoxetine is commonly prescribed during pregnancy but developmental exposure to the drug, like infection, is associated with sex-specific behavioral changes in the offspring. We evaluated the effects of Fluoxetine on production of biomarkers for inflammation (pro/anti-inflammatory cytokines) and neurodevelopment (Brain-Derived Neurotrophic Factor, BDNF) in the presence and absence of infection in female and male placenta explant cultures. In addition to minor anti-inflammatory effects of the drug, Fluoxetine had significant sex- and infection-dependent effects on BDNF production. Further studies are needed to determine the extent to which these observed changes occur in vivo and their impact on pregnancy and neurodevelopmental outcomes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0143400421000710; http://dx.doi.org/10.1016/j.placenta.2021.02.018; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102886271&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/33765533; https://linkinghub.elsevier.com/retrieve/pii/S0143400421000710; https://dx.doi.org/10.1016/j.placenta.2021.02.018
Elsevier BV
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