The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice
Progress in Lipid Research, ISSN: 0163-7827, Vol: 49, Issue: 2, Page: 186-199
2010
- 676Citations
- 530Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations676
- Citation Indexes675
- 675
- CrossRef472
- Patent Family Citations1
- Patent Families1
- Captures530
- Readers530
- 530
Review Description
In mammalian cells, elongases and desaturases play critical roles in regulating the length and degree of unsaturation of fatty acids and thereby their functions and metabolic fates. In the past decade, a great deal has been learnt about these enzymes and the first part of this review summarizes our current knowledge concerning these enzymes. More recently, several transgenic mouse models lacking either an elongase ( Elovl3−/−, Elovl4−/−, Elovl5−/−, Elovl6−/− ) or a desaturase ( Scd-1−/−, Scd-2−/−, Fads2−/− ) have been developed and the second part of this review focuses on the insights gained from studies with these mice, as well as from investigations on cell cultures.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0163782709000678; http://dx.doi.org/10.1016/j.plipres.2009.12.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=76749132709&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/20018209; https://linkinghub.elsevier.com/retrieve/pii/S0163782709000678; https://dx.doi.org/10.1016/j.plipres.2009.12.002
Elsevier BV
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