Pathophysiological role of prostaglandin E synthases in liver diseases
Prostaglandins & Other Lipid Mediators, ISSN: 1098-8823, Vol: 154, Page: 106552
2021
- 5Citations
- 1Captures
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Review Description
Prostaglandin E synthases (PGESs) convert cyclooxygenase (COX)-derived prostaglandin H 2 (PGH 2 ) into prostaglandin E 2 (PGE 2 ) and comprise at least three types of structurally and biologically distinct enzymes. Two of these, namely microsomal prostaglandin E synthase-1 (mPGES-1) and mPGES-2, are membrane-bound enzymes. mPGES-1 is an inflammation-inducible enzyme that converts PGH 2 into PGE 2. mPGES-2 is a bifunctional enzyme that generally forms a complex with haem in the presence of glutathione. This enzyme can metabolise PGH 2 into malondialdehyde and can produce PGE 2 after its separation from haem. In this review, we discuss the role of PGESs, particularly mPGES-1 and mPGES-2, in the pathogenesis of liver diseases. A better understanding of the roles of PGESs in liver disease may aid in the development of treatments for patients with liver diseases.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1098882321000277; http://dx.doi.org/10.1016/j.prostaglandins.2021.106552; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85105519523&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/33930567; https://linkinghub.elsevier.com/retrieve/pii/S1098882321000277; https://dx.doi.org/10.1016/j.prostaglandins.2021.106552
Elsevier BV
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