Quels rôles les anomalies de la voie des nucléotides cycliques et des protéines G jouent-elles dans le désordre biochimique des lymphocytes T dans la sarcoïdose ?
Revue des Maladies Respiratoires, ISSN: 0761-8425, Vol: 30, Issue: 8, Page: 644-656
2013
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Review Description
Le lymphocyte CD4+ joue un rôle important dans la physiopathologie de la sarcoïdose. De nombreux travaux ont exploré les anomalies immunologiques et génétiques du désordre immunitaire engendré par cette maladie. Les recherches concernant des anomalies de grandes voies métaboliques dans la sarcoïdose sont restreintes ; elles concernent principalement les voies STAT1, MAPK38, NF-κB, Gαi, PDE AMPc ou GMPc dépendantes et la PEMT1. À partir de travaux de la littérature et de nos travaux personnels sur certains aspects métaboliques du lymphocyte T dans la sarcoïdose, nous présentons une réflexion sur les différentes hypothèses susceptibles d’entraîner un dysfonctionnement des voies de signalisation mettant en jeu l’AMPc telles que la voie : RAS/RAF/MEK/ERK au niveau du lymphocyte T et pouvant conduire à un processus dysimmunitaire.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0761842513002106; http://dx.doi.org/10.1016/j.rmr.2013.06.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84896695152&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/24182651; https://linkinghub.elsevier.com/retrieve/pii/S0761842513002106; https://dx.doi.org/10.1016/j.rmr.2013.06.003
Elsevier BV
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