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Pregnancy impairs ketone body disposal in late gestating ewes: Implications for onset of pregnancy toxaemia

Research in Veterinary Science, ISSN: 0034-5288, Vol: 81, Issue: 2, Page: 254-264
2006
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The impact of pregnancy on ketone body disposal during a hyperketonaemic clamp was examined by tracer isotope dilution techniques in seven 12 h fasted sheep in three reproductive states, in the dry non-gestating period, late in gestation and during early lactation. After a sampling period of 60 min under basal conditions a DL-BHB racemate solution was continuously infused intravenously for 3 h at rates of 14.3–24.3 μmol/(kg min) to elevate the D-BHB concentration in blood plasma to values between 5 and 7 mmol/l. Two separate experiments were carried out with the same sheep in each of the three reproductive states. During pregnancy three ewes were pregnant with a single lamb and four ewes carried twins. Maximal D-BHB turnover rates fell significantly in late gestation by 26% relative to early lactation and by 22% when compared with the dry non-pregnant state. Reduction of maximal D-BHB disposal rate during late gestation was accompanied by a significant 297% ( p < 0.005) and a non-significant 49% increase in the basal BHB concentration in blood, a non-significant 10% and 4% decrease in the rate constant of D-BHB turnover and a non-significant 24% and 13% rise in the incremented increase of D-BHB concentration per unit D-BHB infusion, relative to the dry and the lactating period, respectively.

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