Enzyme inhibitors from the aril of Myristica fragrans
South African Journal of Botany, ISSN: 0254-6299, Vol: 130, Page: 172-176
2020
- 18Citations
- 61Captures
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Article Description
The fruit aril of Myristica fragrans, commonly known as “mace”, is a popular spice in worldwide. Chromatographic separation of the combined ethyl acetate (EtOAc) and the methanol (MeOH) extracts of the aril of Myristica fragrans furnished malabaricone C ( 1 ), 3-(3-methyl-5-pentyl-2-furanyl)-2( E )-propenoic acid ( 2 ), licarin A ( 3 ), maceneolignan B ( 4 ) and elemicin ( 5 ). Compounds 1–5 were screened for acetylcholinesterase (AChE), and α- glucosidase enzyme inhibitory activities and DPPH radical scavenging activity. Compound 1 showed the highest AChE inhibitory activity (IC 50 2.06 ± 0.04 μg/mL) and antioxidant activity (IC 50 6.56 ± 0.02 μg/mL) while compound 2 displayed the most potent α -glucosidase inhibitory activity (IC 50 50.91 ± 0.01 μg/mL). This is the first report of α -glucosidase inhibitory activity of 2. Results indicate that the aril of M. fragrans showed good anticholinesterase and α -glucosidase inhibitory activities and antioxidant effect in-vitro that have a potential to be used as the treatment of Alzheimer's disease.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0254629919314462; http://dx.doi.org/10.1016/j.sajb.2019.12.020; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077656715&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0254629919314462; https://dx.doi.org/10.1016/j.sajb.2019.12.020
Elsevier BV
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