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Decoding eggplant fruit: Multi-omics profiling of caffeoyl-CoA-3-OMT expression

South African Journal of Botany, ISSN: 0254-6299, Vol: 174, Page: 551-559
2024
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  • Captures
    2
  • Mentions
    1
    • News Mentions
      1
      • News
        1

Most Recent News

Researchers from Chaudhary Charan Singh Haryana Agricultural University Describe Findings in Life Science (Decoding Eggplant Fruit: Multi-omics Profiling of Caffeoyl-coa-3-omt Expression)

2024 NOV 06 (NewsRx) -- By a News Reporter-Staff News Editor at Health & Medicine Daily -- Current study results on Life Science have been

Article Description

Eggplant ( Solanum melongena L.) is a rich source of health-promoting phenolic acids, mainly chlorogenic acid (CGA), and trace elements. CGA has been shown to have antioxidant, anti-inflammatory, neuroprotective, cardioprotective, anticancer, and antidiabetic properties. The natural genome of eggplants contains essential genes for beneficial traits like drought tolerance, disease resistance, and high concentrations of medicinal substances. Transcriptomic analysis of eggplant overexpressing the hydroxycinnamoyl CoA quinate hydroxycinnamoyl transferase (HQT) gene revealed upregulation of 2165 genes, including three similar to HQT and cinnamate-4-hydroxylase (C4H). Sequence similarity analysis showed homology to caffeoyl-CoA O-methyltransferases, key enzymes in the phenylpropanoid pathway leading to CGA biosynthesis. Gene ontology and KEGG pathway analysis identified 5 highly upregulated glycosyltransferase family 43 genes (650.3-fold change). Glycosyltransferases like UDP-glucose:cinnamate glucosyltransferase and cinnamate-glucose 4′-O-glucosyltransferase are crucial for CGA production in eggplant. qRT-PCR validated the potential upregulation of HQT and C4H in transgenic eggplants. Comparative analysis revealed eggplant has the highest CGA content (5–8.1 g/kg dry weight) among vegetables, with foliar CGA acting as a natural insecticide. CGA offers antioxidant, hypoglycemic, antiviral, and hepatoprotective benefits to humans. This study highlights the role of HQT and C4H in elevating the medicinal properties of eggplant through CGA biosynthesis pathway engineering.

Bibliographic Details

Kirtan Dave; Prashant Kaushik; Nil Patil; Rupal Dhariwal; Meenakshi Sharma; Alpa Yadav; Parmdeep Singh Dhanda; Mukul Jain

Elsevier BV

Agricultural and Biological Sciences

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