Occurrence, environmental fate, ecological issues, and redefining of endocrine disruptive estrogens in water resources

The growing persistence of estrogenic pollutants in water resources is a worrying concern because of their endocrine disrupting activities and potentially hazardous consequences on the environmental matrices, ecology, and human health, even at low concentration. The long-term persistence of steroidal estrogens leads to their bioaccumulation in aquatic organisms that can further reach to humans via food chain route. Considering the toxicity of steroidal estrogens, it is important to mitigate these environmentally related hazardous contaminants. So far, several treatment methods, like adsorption, oxidation, irradiation, and electrochemical techniques have been proposed to eliminate estrogens from aqueous ecosystems. Nevertheless, high operational costs, insufficient removal, generation of toxic sludge, and the necessity of skilled maintenance and operating workers are the major hindrances associated with large scale applications. Bioremediation of steroidal estrogens using enzyme-based biocatalytic system has recently emerged as a promising alternative to remove and bio-transform estrogens from aqueous systems. However, the current literature lacks a critique focusing specifically and comprehensively on steroidal estrogens. The presented review is a critical assessment of the existing literature on steroid-based endocrine disruptive estrogens. A detailed description about the occurrence and eco-fate of steroidal estrogens is given with representative examples. The later half of the review stresses on the redefining (removal) of endocrine disruptive estrogens in water resources with particular reference to enzyme-based approaches.