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Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against Culex quinquefasciatus and molecular docking studies

Saudi Journal of Biological Sciences, ISSN: 1319-562X, Vol: 29, Issue: 4, Page: 2389-2395
2022
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The pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on Culex quinquefasciatus larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, 1 H NMR, 13 C NMR, mass spectrometry, and elemental analysis. Synthesized compounds ( 1a-h ) were evaluated for larvicidal activities. Compound 1e (LD 50 : 26.06 µg/mL), and 1f (LD 50 : 26.89 µg/mL), and were notably more active against Culex quinquefasciatus than permethrin (LD 50 : 26.14 µg/mL). The docking studies also demonstrated that 1e, and 1f are potent larvicides with higher binding energy (−12.6 kcal/mol) than the control in the mosquito odorant binding protein (PDB ID: 3OGN). The larvicidal properties of lead molecules have made them important for use as insecticides.

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