Mosquito larvicidal activity of pyrrolidine-2,4-dione derivatives: An investigation against Culex quinquefasciatus and molecular docking studies
Saudi Journal of Biological Sciences, ISSN: 1319-562X, Vol: 29, Issue: 4, Page: 2389-2395
2022
- 4Citations
- 17Captures
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Metrics Details
- Citations4
- Citation Indexes4
- Captures17
- Readers17
- 17
Article Description
The pyrrolidine-2,4-dione derivatives were used to conduct a larvicidal test on Culex quinquefasciatus larvae of the second instar. Mannich base condensation method was used to synthesis the pyrrolidine-2,4-dione derivatives by grindstone method. The reaction conditions were mild, resulting in high yields. An analysis of the synthesized compounds was carried out using FTIR, 1 H NMR, 13 C NMR, mass spectrometry, and elemental analysis. Synthesized compounds ( 1a-h ) were evaluated for larvicidal activities. Compound 1e (LD 50 : 26.06 µg/mL), and 1f (LD 50 : 26.89 µg/mL), and were notably more active against Culex quinquefasciatus than permethrin (LD 50 : 26.14 µg/mL). The docking studies also demonstrated that 1e, and 1f are potent larvicides with higher binding energy (−12.6 kcal/mol) than the control in the mosquito odorant binding protein (PDB ID: 3OGN). The larvicidal properties of lead molecules have made them important for use as insecticides.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1319562X21010366; http://dx.doi.org/10.1016/j.sjbs.2021.12.003; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85123004871&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35531199; https://linkinghub.elsevier.com/retrieve/pii/S1319562X21010366; https://dx.doi.org/10.1016/j.sjbs.2021.12.003
Elsevier BV
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