Enhancing circulating tumor cells separation with integrated spiral and U-shaped cross-section microchannels using elasto-inertial microfluidics
Sensors and Actuators A: Physical, ISSN: 0924-4247, Vol: 382, Page: 116153
2025
- 15Captures
- 1Mentions
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- Captures15
- Readers15
- 15
- Mentions1
- News Mentions1
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New Cancer Research Study Findings Recently Were Reported by Researchers at Iranian Research Organization for Science and Technology (Enhancing Circulating Tumor Cells Separation With Integrated Spiral and U-shaped Cross-section Microchannels ...)
2025 FEB 05 (NewsRx) -- By a News Reporter-Staff News Editor at Middle East Daily -- Researchers detail new data in Cancer Research. According to
Article Description
The integration of microfluidic devices for isolating circulating tumor cells (CTCs) from blood samples is essential for cancer diagnosis and monitoring. CTCs are extremely rare compared to other blood cells, requiring precise and efficient microfluidic systems. Recent advancements in elasto-inertial microfluidic devices using viscoelastic fluids have demonstrated high throughput and exceptional separation accuracy, enabling precise control of particle and cell movement, rapid and accurate blood sample processing, and high cell viability, making microfluidic systems an ideal platform for blood cell processing and separation. An integrated microfluidic system with a spiral section and a curved microchannel featuring a U-shaped cross-section was developed for separating blood cells/particles of 7 μm (Red Blood Cells, RBCs) and 22 μm (CTCs) in diameter. The U-shaped cross-section generates two longitudinal vortices, directing particles toward the outer wall, enhancing separation resolution and efficiency. Finite element method (FEM) simulations were used to study particle migration within the microchannel. Simulation results showed 100 % separation efficiency of 22 μm particles (CTCs) from 7 μm particles (RBCs) at an optimal inlet flow rate of 250 μl/min. Experimental tests confirmed a recovery rate of 98.6 % for CTCs and 97.7 % for RBCs at target outlets. The integrated microchannel demonstrated a high separation efficiency of 98 % at 250 μl/min, surpassing other elasto-inertial viscoelastic fluid devices in efficiency and speed. The development of this integrated microfluidic system represents a significant advancement in CTC isolation, offering rapid and accurate separation of target cells from blood samples. This technology enhances cancer diagnostics and monitoring by providing a high-efficiency solution for isolating rare CTCs, surpassing existing methods in both speed and accuracy.
Bibliographic Details
Elsevier BV
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