A novel self-enhancement NCNDs-BPEI-Ru nanocomposite with highly efficient electrochemiluminescence as signal probe for ultrasensitive detection of MTB
Sensors and Actuators B: Chemical, ISSN: 0925-4005, Vol: 354, Page: 131252
2022
- 6Citations
- 4Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Herein, a novel self-enhanced Ru(Ⅱ)-based nanocomposite (NCNDs-BPEI-Ru), synthesized by covalently connecting nitrogen-doped carbon nanodots (NCNDs) and tris (4,4′-dicarboxylicacid-2,2′-bipyridyl) ruthenium (II) dichloride (Ru(dcbpy) 3 Cl 2 ) through branched polyethyleneimine (BPEI), could be used as an electrochemiluminescence (ECL) signal probe for ultrasensitive detection of mycobacterium tuberculosis (MTB) DNA fragment. Without any extraneous coreactants, NCNDs-BPEI-Ru could generate an ultra-strong initial ECL signal on the glassy carbon electrode (GCE) (signal-on) due to the coreaction from BPEI and NCNDs to Ru(dcbpy) 3 Cl 2. Then, self-assembled DNA nanotubes embedding methylene blue molecules (MB-DNANTs) were modified on the nanocomposite to effectively quench the ECL intensity of NCNDs-BPEI-Ru owing to the quenching effect of MB for Ru(dcbpy) 3 Cl 2 (signal-off). Finally, the 3D DNA nanomachine, formed by a DNA-functionalized magnetic beads (DNA-MBs) could transform trace target MTB into massive output DNA, and the MB-DNANTs could be disintegrated to get ECL signal recovery (signal-on) due to hybridization of output DNA and the S2 in DNANTs. Therefore, the proposed biosensor exhibited predominant performance for the detection of MTB DNA fragment with a low detection limit of 1.4 aM, which showed great application value in the detection of biomarkers in clinical diagnosis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0925400521018207; http://dx.doi.org/10.1016/j.snb.2021.131252; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85121218153&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0925400521018207; https://dx.doi.org/10.1016/j.snb.2021.131252
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know