Prognostic impact of the CALLY index in patients with resectable pancreatic cancer
Surgical Oncology Insight, ISSN: 2950-2470, Vol: 2, Issue: 1, Page: 100119
2025
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
The prognostic significance of the preoperative C-reactive protein-albumin-lymphocyte (CALLY) index has been reported in various cancers. However, its role in pancreatic cancer remains unclear. A cohort of 307 patients with resectable pancreatic cancer (RPC) who underwent curative surgery without neoadjuvant therapy, between July 2012 and December 2019, was analyzed. The CALLY index was defined as (albumin × lymphocytes)/ (C-reactive protein × 10 4 ). The cutoff value of the CALLY index was determined according to receiver operating characteristics analysis using survival status at 3-year follow-up. The association of the CALLY index with disease-free survival (DFS) and overall survival (OS) was investigated using univariate and multivariate analyses. The median CALLY index was 4.5, with an interquartile range of 1.4–12.3. The cutoff value of the CALLY index was set at 3.0, dividing patients into a CALLY-high group (> 3.0; n = 180) and a CALLY-low group (≤ 3.0; n = 127). The DFS and OS were significantly worse in the CALLY-low group versus the CALLY-high group ( p < 0.001 and p < 0.001, respectively). Multivariate analysis, using preoperative clinicopathological variables, revealed a CALLY index ≤ 3.0 as an independent prognostic factor for DFS (hazard ratio [HR] 1.43, p = 0.041) and OS (HR 1.56, p = 0.012). In RPC, survival outcomes were significantly stratified by the CALLY index = 3.0, with < 3 being a significantly poor prognostic factor for DFS and OS. The CALLY index may be useful in predicting long-term survival in patients with RPC.
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