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Notching Up MYC Gives a LIC

Cell Stem Cell, ISSN: 1934-5909, Vol: 13, Issue: 1, Page: 8-9
2013
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Article Description

In a recent issue of Cell, King et al. (2013) show that mutations in the ubiquitin ligase subcomponent FBXW7 increase MYC protein levels and expand the number of leukemia-initiating cells (LICs) in Notch1-induced T-ALL. Genetic and pharmacological inhibition of MYC abolishes LIC activity with broader therapeutic implications.

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