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Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming

Cell Stem Cell, ISSN: 1934-5909, Vol: 14, Issue: 5, Page: 561-574
2014
  • 465
    Citations
  • 0
    Usage
  • 650
    Captures
  • 2
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    465
  • Captures
    650
  • Mentions
    2
    • News Mentions
      1
      • News
        1
    • References
      1
      • Wikipedia
        1

Most Recent News

Acquisition of epithelial plasticity in human chronic liver disease

Nature, Published online: 22 May 2024; doi:10.1038/s41586-024-07465-2 Single-cell RNA sequencing and 3D imaging have revealed the cellular changes and structural reorganization that occur during the progression of human chronic liver disease and as the liver attempts to regenerate.

Review Description

The liver is a central organ for homeostasis with unique regenerative capacities. Mature hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to discern the role of adult liver stem cells in this process. In contrast, stem/progenitor cells in the developing liver have been extensively characterized, and these investigations have informed efforts to produce functional hepatocytes in vitro for cell therapy and drug screening. In this Review, we describe recent advances in the characterization of liver stem cells and discuss evidence supporting and refuting whether self-renewable and bipotential liver stem cells exist in development, homeostasis, regeneration, and disease.

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