Gut-Barrier Disruption After Laparoscopic Versus Open Major Liver Resection in the Rat
Surgery, ISSN: 0039-6060, Vol: 171, Issue: 4, Page: 973-979
2022
- 5Citations
- 12Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations5
- Citation Indexes5
- CrossRef1
- Captures12
- Readers12
- 12
Article Description
Major liver resection may compromise gut-barrier function, increasing the risk of postoperative infectious complications. The aim of the present experimental study was to compare the effect of the laparoscopic versus the open technique for major liver resection on integrity as well as inflammatory and immune responses of the gut barrier. Wistar rats were subjected to open 70% hepatectomy (group H), laparoscopic 70% hepatectomy (group LH), sham operation (group S) or no intervention (group C). At various timepoints (1 hour–1 week) after operation, ileal tissue was excised for oxidative state assessment (TBARS levels), histopathologic examination, histomorphometric analysis, immunohistochemical assessment of the mitotic and apoptotic activity, and tissue expression of inflammatory (interleukin-6, tumor necrosis factor-α, nuclear factor-κB and vascular cell adhesion molecule-1) and immune response biomarkers (CD4 + and CD8 + T-lymphocytes) of the intestinal mucosa. No changes were noted in oxidative state. The histopathologic profile was less deteriorated in group LH compared to group H. Intestinal mucosa atrophy was less intense in group LH compared to group H and was related to an equally compromised crypt cell mitotic activity. Tissue overexpression of interleukin-6, tumor necrosis factor-α, nuclear factor-κΒ, vascular cell adhesion molecule-1, CD4 +, and CD8 + T-lymphocytes was less pronounced in group LH compared to group H. The employment of the laparoscopic technique for major liver resection in the rat attenuated disruption of the gut barrier compared to the open procedure. This was related to less pronounced inflammatory and immune responses of the intestinal mucosa.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0039606021011089; http://dx.doi.org/10.1016/j.surg.2021.11.002; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85120640298&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/34876288; https://linkinghub.elsevier.com/retrieve/pii/S0039606021011089; https://dx.doi.org/10.1016/j.surg.2021.11.002
Elsevier BV
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