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Links between metabolic syndrome and metabolic dysfunction-associated fatty liver disease

Trends in Endocrinology & Metabolism, ISSN: 1043-2760, Vol: 32, Issue: 7, Page: 500-514
2021
  • 121
    Citations
  • 0
    Usage
  • 123
    Captures
  • 2
    Mentions
  • 17
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    121
  • Captures
    123
  • Mentions
    2
    • News Mentions
      2
      • 2
  • Social Media
    17
    • Shares, Likes & Comments
      17
      • Facebook
        17

Most Recent News

Serum Lactate Dehydrogenase Is a Novel Predictor for the Severity in the Patients With MAFLD: A Cross-Sectional Study in Hefei, China

Introduction As one of the metabolic disorders, metabolism-associated fatty liver disease (MAFLD) affects the majority of obese patients and is associated with a range of

Review Description

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a chronic condition characterized by hepatic fat accumulation combined with underlying metabolic dysregulation. Having evolved from the previous term of nonalcoholic fatty liver disease (NAFLD), the term MAFLD more closely implicates the presence of overweight/obesity, type 2 diabetes, or metabolic dysregulation as essential pathogenic factors, leading to better identification of individuals with this metabolic liver disease. Low-grade inflammation, increased oxidative stress, mitochondrial dysfunction, and intestinal dysbiosis are also involved in its pathogenesis. MAFLD is not only associated with liver-related complications, but also with adverse cardiometabolic outcomes. Further studies are needed to assess whether the newly proposed definition of MAFLD is more accurate than the NAFLD in predicting the adverse liver-related and extrahepatic outcomes.

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