Hypothalamic mechanisms of obesity-associated disturbance of hypothalamic–pituitary–ovarian axis
Trends in Endocrinology & Metabolism, ISSN: 1043-2760, Vol: 33, Issue: 3, Page: 206-217
2022
- 42Citations
- 48Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations42
- Citation Indexes42
- 42
- CrossRef10
- Captures48
- Readers48
- 48
Review Description
Ovulatory disorders are the most common clinical feature exhibited among obese women. Initiation of ovulation physiologically requires a surge of gonadotropin-releasing hormone (GnRH) released from GnRH neurons located in the hypothalamus. These GnRH neurons receive metabolic signals from circulation and vicinal neurons to regulate GnRH release. Leptin acts indirectly on GnRH via adjacent leptin receptor (LEPR)-expressing neurons such as proopiomelanocortin (POMC), neuropeptide Y (NPY)/agouti-related peptide (AgRP), and neuronal nitric oxide (NO) synthase (nNOS) neurons to affect GnRH neuronal activities. Additionally, hypothalamic inflammation also affects ovulation independent of obesity. Therefore, this review focuses on hypothalamic mechanisms that underlie the disturbance of hypothalamic–pituitary–ovarian (HPO) axis during obesity with an attempt to promote future studies and/or novel therapeutic strategies for ovulatory disorders in obesity.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S1043276021002988; http://dx.doi.org/10.1016/j.tem.2021.12.004; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85123082438&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/35063326; https://linkinghub.elsevier.com/retrieve/pii/S1043276021002988; https://dx.doi.org/10.1016/j.tem.2021.12.004
Elsevier BV
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