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Stereoselective syntheses of (−)-chloramphenicol and (+)-thiamphenicol

Tetrahedron, ISSN: 0040-4020, Vol: 62, Issue: 38, Page: 8959-8965
2006
  • 35
    Citations
  • 0
    Usage
  • 15
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    35
    • Citation Indexes
      35
  • Captures
    15

Article Description

Chloramphenicol and thiamphenicol have been enantioselectively synthesized using an asymmetric halohydrin reaction as a key step. In particular, halomethoxylation reaction was used, where O -methyl functions as a hydroxyl protecting group and eliminates an additional protection step.

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