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Metathesis cascade strategies (ROM–RCM–CM): a DOS approach to skeletally diverse sultams

Tetrahedron, ISSN: 0040-4020, Vol: 65, Issue: 26, Page: 4992-5000
2009
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Article Description

The development of a ring-opening metathesis/ring-closing metathesis/cross-metathesis (ROM–RCM–CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels–Alder (IMDA) reactions undergo metathesis cascades to yield a collection of tricyclic sultams. Additional appendage-based diversity was achieved by utilizing a variety of CM partners.

Bibliographic Details

Jeon, Kyu Ok; Rayabarapu, Dinesh; Rolfe, Alan; Volp, Kelly; Omar, Iman; Hanson, Paul R

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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