DBU-promoted tandem Michael-addition/cyclization for the synthesis of polysubstituted pyrroles
Tetrahedron, ISSN: 0040-4020, Vol: 75, Issue: 15, Page: 2291-2297
2019
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
An efficient and transition-metal-free method for the synthesis of the structurally diversified pyrroles is described. Various α,β -unsaturated ynones reacted with N -substituted ethyl glycine ethyl ester hydrochlorides in the presence of DBU to form the corresponding products in good yields. This protocol has the advantages of readily available starting materials, mild reaction conditions and a wide scope of substrates, which provides a practical route for the synthesis of polysubstituted pyrroles.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0040402019302170; http://dx.doi.org/10.1016/j.tet.2019.02.057; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85062302047&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0040402019302170; https://dx.doi.org/10.1016/j.tet.2019.02.057
Elsevier BV
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