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Red-emitting rhodamine-based probe with large Stokes shift for ClO − detection

Tetrahedron, ISSN: 0040-4020, Vol: 127, Page: 133020
2022
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Article Description

A fluorescent rhodamine dye, HN, was prepared by introducing tetrahydroquinoxalinyl donor, which displayed far-red emission (687 nm), large Stokes shift (84 nm), and relatively high fluorescent quantum yield (0.33). Based on HN dye, a fluorescent probe, HN-HClO, was developed for hypochlorite (ClO − ) detection. The probe HN-HClO exhibited fast response time (within 100 s), excellent sensitivity (LOD = 74 nM), and good selectivity toward ClO −. The probe HN-HClO was capable of imaging ClO − in both living cells and zebrafish. It could also monitor the endogenously generated ClO − in the MPO-catalyzed system.

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