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One-step synthesis of 4-methyl-2-substituted quinazoline-3-oxides via polyphosphoric acid catalyzed acylation of electron-rich anilides with nitroethane

Tetrahedron, ISSN: 0040-4020, Vol: 151, Page: 133784
2024
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Article Description

A diverse set of 4-methyl-2-substituted quinazoline-3-oxides has been prepared using polyphosphoric acid both as a reaction medium and a Brønsted-acid catalyst. The reaction proceeds in a domino fashion via the formation of a corresponding oxime followed by exo-trig cyclization and elimination of a water molecule which leads, ultimately, to the target N -oxide heterocycles.

Bibliographic Details

Igor Yu Grishin; Alexander V. Aksenov; Nicolai A. Aksenov; Yuriy I. Grishin; Alexander V. Leontiev; Dmitrii A. Aksenov

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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