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(4+2) cyclization of benzofuran derived oxa-dienes with malononitrile for construction of benzofuranopyran framework

Tetrahedron, ISSN: 0040-4020, Vol: 153, Page: 133822
2024
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Article Description

A (4 + 2)-cyclization of benzofuran derived oxa-dienes with malononitrile was established, and benzofuranopyrans with potential antitumor activity were synthesized in generally good yields (up to 85 %). This reaction not only has confronted the challenges in developing (4 + 2)- cyclization involving benzofuran derived oxa-dienes, but also provides an atom-economic method for the construction of biologically important benzofuranopyran frameworks.

Bibliographic Details

Qiong Wu; Shuang Yang; Yi-Ming Tian; Tian-Zi Huang; Xiao-Qin Shi; Wei-Dan Na; Tian-Shu Zhang; Shuai Liu; Tong-Xiang Li

Elsevier BV

Biochemistry, Genetics and Molecular Biology; Pharmacology, Toxicology and Pharmaceutics; Chemistry

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