A facile one-pot domino reaction for the stereoselective synthesis of acryl derivatives promoted by Ca(OTf) 2

A facile one-pot domino reaction for the stereoselective synthesis of acryl derivatives has been reported using alkaline earth catalyst [Ca(OTf) 2 ]. Initially aryl amine reacts with ethyl propiolate to form β-enamino ester which further reacts with aryl aldehyde and indole in the presence of Ca(OTf) 2 to give indolyl acrylates. It is interesting to note that in the absence of indole the reaction leads to the formation of benzylidene bisacrylates. Similarly β-enamino ester reacts with another electrophilic partner isatin in the presence of Ca(OTf) 2 to give oxindolyl acrylates. The products were isolated in good yields by simple filtration.