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Pyrrole acetylenecarbaldehydes: an entry to a novel class of functionalized pyrroles

Tetrahedron Letters, ISSN: 0040-4039, Vol: 57, Issue: 45, Page: 4961-4964
2016
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Article Description

The first representatives of a previously unknown class of highly reactive functionalized pyrrole compounds, 3-(pyrrol-2-yl)propiolaldehydes, have been synthesized by the transition metal-free, mechanoactivated ethynylation of pyrroles with 3-iodopropiolaldehyde using a solid K 2 CO 3 medium under mild conditions (room temperature, 4 h) in yields of up to 71%.

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