A green protocol for one pot synthesis of benzosuberone tethered thiadiazolopyrimidine-6-carboxylates using PEG-400 as potent anti-proliferative agents
Tetrahedron Letters, ISSN: 0040-4039, Vol: 59, Issue: 31, Page: 3015-3019
2018
- 13Citations
- 18Captures
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Article Description
A new concise and facile method was explored to synthesize a collection of new benzosuberone based thiadiazolo [3,2- a ] pyrimidine-6-carboxylates using polyethylene glycol (PEG), which could be regarded as the derivatives of the hybrid scaffolds of bioactive natural benzosuberone and heterocyclic thiadiazolo[3,2- a ]pyrimidine. The structures of the synthesized compounds were characterized by 1 H, 13 C NMR, MS and IR; and their anti-proliferative activity was evaluated against four human cancer cell lines; A549, SKNSH, HeLa and MCF-7. Among the tested compounds, compound 8k showed the most prominent activity against all the cell lines and these results may lay the foundation for further design of novel anti-proliferative agents.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0040403918308475; http://dx.doi.org/10.1016/j.tetlet.2018.06.068; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85049344798&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/S0040403918308475; https://dul.usage.elsevier.com/doi/; https://api.elsevier.com/content/article/PII:S0040403918308475?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:S0040403918308475?httpAccept=text/plain; https://dx.doi.org/10.1016/j.tetlet.2018.06.068
Elsevier BV
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