Antithrombin activity of lepirudin adsorbed to silicone (polydimethylsiloxane) tubing
Thrombosis Research, ISSN: 0049-3848, Vol: 112, Issue: 1, Page: 111-115
2003
- 9Citations
- 10Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Article Description
Because venous access devices are associated with thrombosis, attempts have been made to make the catheter material less thrombogenic. We have found that the protein anticoagulant lepirudin readily adsorbs to silicone tubing and retains some anti-thrombin activity that is not removed by washing with saline buffer or immersion in whole blood. Therefore, lepirudin treatment of silicone catheters may render them thromboresistant and should be tested in animal models.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0049384803005383; http://dx.doi.org/10.1016/j.thromres.2003.10.009; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0842303027&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/15013282; https://linkinghub.elsevier.com/retrieve/pii/S0049384803005383; https://dx.doi.org/10.1016/j.thromres.2003.10.009
Elsevier BV
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