Gene dosage imbalances: action, reaction, and models
Trends in Biochemical Sciences, ISSN: 0968-0004, Vol: 40, Issue: 6, Page: 309-317
2015
- 46Citations
- 111Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations46
- Citation Indexes46
- 46
- CrossRef44
- Captures111
- Readers111
- 111
- Mentions1
- News Mentions1
- News1
Review Description
Single-gene deletions, duplications, and misregulation, as well as aneuploidy, can lead to stoichiometric imbalances within macromolecular complexes and cellular networks, causing their malfunction. Such alterations can be responsible for inherited or somatic genetic disorders including Mendelian diseases, aneuploid syndromes, and cancer. We review the effects of gene dosage alterations at the transcriptomic and proteomic levels, and the various responses of the cell to counteract their effects. Furthermore, we explore several biochemical models and ideas that can provide the rationale for treatments modulating the effects of gene dosage imbalances.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/S0968000415000602; http://dx.doi.org/10.1016/j.tibs.2015.03.011; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=84929502864&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/25937627; https://linkinghub.elsevier.com/retrieve/pii/S0968000415000602
Elsevier BV
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